Memorial Hospital Research Laboratories

The Elli Papaemmanuil Lab

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Research

Elli Papaemmanuil, PhD

Our lab is a collective of clinical, computational, molecular and mathematic research investigators with an interest to study the role of acquired mutations in cancer development and how these determine clinical phenotype and response to therapy. Our mission is to execute research that informs and moves clinical practices in oncology forward. We have strong expertise in genome profiling analysis proven track record on the development of high-throughput laboratory and analytical pipelines (bioinformatics and statistical) and integrate large and complex genomic datasets. We have formed a strong network of research and clinical collaborations, to pursue innovative studies in cancer research.

We like to perform ambitious research but operate in a fun, collaborative and team oriented environment and we are strongly committed to mentoring young scientists through internal and international internship schemes.

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Research Projects

Featured News

In the Clinic
New Research Shows AML Is Not One Disease, But 11 or More

Publications

Papaemmanuil E, Rapado I, Li Y, Potter NE, Wedge DC, Tubio J, Alexandrov LB, Van Loo P, Cooke SL, Marshall J, Martincorena I, Hinton J, Gundem G, van Delft FW, Nik-Zainal S, Jones DR, Ramakrishna M, Titley I, Stebbings L, Leroy C, Menzies A, Gamble J, Robinson B, Mudie L, Raine K, O’Meara S, Teague JW, Butler AP, Cazzaniga G, Biondi A, Zuna J, Kempski H, Muschen M, Ford AM, Stratton MR, Greaves M, Campbell PJ. RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia. Nat Genet. 2014 Feb;46(2):116-25. doi: 10.1038/ng.2874. Epub 2014 Jan 12. PubMed Central PMCID: PMC3960636. PubMed

Gerstung M, Pellagatti A, Malcovati L, Giagounidis A, Porta MG, Jädersten M, Dolatshad H, Verma A, Cross NC, Vyas P, Killick S, Hellström-Lindberg E, Cazzola M, Papaemmanuil E, Campbell PJ, Boultwood J. Combining gene mutation with gene expression data improves outcome prediction in myelodysplastic syndromes. Nat Commun. 2015 Jan 9;6:5901. doi: 10.1038/ncomms6901. PubMed Central PMCID: PMC4338540. PubMed

Gerstung M, Papaemmanuil E, Campbell PJ. Subclonal variant calling with multiple samples and prior knowledge. Bioinformatics. 2014 May 1;30(9):1198-204. doi: 10.1093/bioinformatics/btt750. Epub 2014 Jan 16. PubMed Central PMCID: PMC3998123. PubMed

Papaemmanuil E, Gerstung M, Malcovati L, Tauro S, Gundem G, Van Loo P, Yoon CJ, Ellis P, Wedge DC, Pellagatti A, Shlien A, Groves MJ, Forbes SA, Raine K, Hinton J, Mudie LJ, McLaren S, Hardy C, Latimer C, Della Porta MG, O’Meara S, Ambaglio I, Galli A, Butler AP, Walldin G, Teague JW, Quek L, Sternberg A, Gambacorti-Passerini C, Cross NC, Green AR, Boultwood J, Vyas P, Hellstrom-Lindberg E, Bowen D, Cazzola M, Stratton MR, Campbell PJ; Chronic Myeloid Disorders Working Group of the International Cancer Genome Consortium. Clinical and biological implications of driver mutations in myelodysplastic syndromes. Blood. 2013 Nov 21;122(22):3616-27; quiz 3699. doi: 10.1182/blood-2013-08-518886. Epub 2013 Sep 12. PubMed Central PMCID: PMC3837510. PubMed

Papaemmanuil E, Hosking FJ, Vijayakrishnan J, Price A, Olver B, Sheridan E, Kinsey SE, Lightfoot T, Roman E, Irving JA, Allan JM, Tomlinson IP, Taylor M, Greaves M, Houlston RS. Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia. Nat Genet. 2009 Sep;41(9):1006-10. doi: 10.1038/ng.430. Epub 2009 Aug 16. PubMed

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People

Elli Papaemmanuil, PhD

  • Molecular geneticist Elli Papaemmanuil performs systematic interrogations of well-annotated clinical trial cohorts in leukemia and cancer to explore how the compound genetic and clonal architecture in patients' leukemias and tumors dictate clinical phenotype, disease progression, and clinical outcomes.
  • PhD – University of London, London, England, UK
papaemme@mskcc.org
Email Address
646-888-3158
Office Phone

Members

Juan E. Arango-Ossa

Bioinformatics Engineer III

Georgios Asimomitis

Computational Biologist II

Elsa Bernard

Research fellow

Kelly Bolton

Instructor

Teng Gao

Computational Biologist II

Gunes Gundem

Research Fellow

Jesus Gutierrez-Abril

Research Fellow

Max Levine

Senior Computational Biologist I

Joseph G. McCarter

Computational Biologist, Sr I

Noushin Rahnamay Farnoud

Computational Biologist, Sr II

Kayleigh Rutherford

Computational Biologist II

Maria Sirenko

GSK Graduate Student

Yanis Tazi

Graduate Student, Tri-I Institutional PhD Program

Yangyu Zhou

Bioinformatics Engineer II

Lab Alumni
Seon Ball

Administrative Assistant II

Antonin Berthon

Graduate Research Assistant

Maheetha Bharadwaj

Computational Biologist I

Matthieu Cornet

Graduate Research Assistant

Marc Robert de Massy

Visiting scientists

Andre Deslauriers

Graduate Research Assistant

Dominik Glodzik

Associate Manger, Computational Biologist

Pierre F. Guilmin

Graduate Research Assistant

Juan Medina

Bioinformatics Engineer II, Leukemia Genomics

Matahi Moarii

Research Fellow

Yoann Pradat

Graduate Research Asst

Komal Rathi

Bioinformatics Engineer II, Leukemia Genomics

Yellapantula Venkata

Bioinformatics Engineer II

Elliot Youth

Intern

Lab Affilations

Achievements

  • European Hematology Association Young Investigator Award
  • Cancer Research UK Career Development Award

Open Positions

Bioinformatics Data Scientist

The bioinformatics data scientist will work with an expanding team of research, clinical and computational investigators working in cancer genomics.

Apply now

Careers

Positions available: Statistical learning We are planning large-scale single-cell and population genomics sequencing studies and are looking for a motivated and driven masters or PhD level candidates with experience in statistical learning and advanced modeling methodologies to join out team.

Apply now

Molecular genomics, Research Assistant / Senior Research Technician

We are an expanding team of research, clinical and computational investigators working in cancer genomics with a focus in blood and childhood cancers.

Apply now

View All Open Positions

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